Sander Kleinenberg began DJ-ing at a local bar in 1987 at the age of 15, playing a variety of music including rock and dance music. After sending demos to many European record labels, Kleinenberg released his first single under the name Free Frogs, a band which he formed with several friends. The record, titled "Bombay", was released in 1993 on Belgian record label Wonka Beats. The next year, he released a single on German record label Superstition. In 1996, Kleinenberg released "YDW (You Do Me Wrong)" under the moniker S 'N' S on the Dutch record label Deal Records and licensed by Strictly Rhythm. His early influences included Mantronix, Shep Pettibone, and Depeche Mode.

In 1999, Kleinenberg produced the first part of his thematic 4 Seasons trilogy with second part the following in 2000. Kleinenberg was also becoming known worldwide with the release of his track "My Lexicon", which is now often considered a genre standard of progressive house. "My Lexicon" is well known for its catchy, trancey percussive melody and atmospheric chord stabs. "My Lexicon" and "Sacred" were both given a boost in popularity by their appearance on Sasha's Global Underground 013: Ibiza album. Kleinenberg got his chance on Global Underground the following year with his Nubreed 004 release.

In 2003, Sander Kleinenberg founded his record label Little Mountain Recordings. Its first release was the final part in Kleinenberg's 4 Seasons series, which had been pushed back due to, among other things, label changes. Kleinenberg described the final installment as "rougher around the edges" rather than having the trancey serenity of the first or the funkiness of the second. He also remixed Justin Timberlake's single "Rock Your Body", which garnered him the Best Remix award at the Dancestar USA Awards. Later in 2003, Kleinenberg kicked off the introduction of his "Everybody" brand with the album Renaissance: Everybody which featured a mixture of quirky disco, Detroit techno, and tech house. Kleinenberg described the concept of "Everybody" as "a reaction to how dance music began to take itself too seriously" and that he hopes to show that dance music can be fun. He followed Everybody up the next year with a sequel, This Is Everybody Too, which continued Kleinenberg's vein of "glitchy, low key techno".

In 2005, Kleinenberg began a monthly residency at Crobar, New York, using it to push the "Everybody" brand.[14] He also brought in Lee Burridge to Crobar and to work on the album This is Everybody! On Tour.[14] Kleinenberg's performances at Crobar often featured appearances from young DJs, such as Desyn Masiello.[14] Over his career, Kleinenberg's track selection shifted from the more "lush" sounds of progressive house to a funkier electro house vibe, though he prefers to define his genre simply as "house music". In 2004 he had released his track The Fruit and in 2006 he released This is Miami, both tracks reached a number one position in the ARIA chart.  His "Everybody" brand has grown with the years and has changed to his current "This Is..." brand which was influendce by his song "This Is Miami", another version of the song which was used in the Sensation (event) is called, "This Is Sensation".

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